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Structure 3 was identified as the new lead from 3-D QSAR studies. Unfortunately, compound 3 suffered from poor water solubility. Propose a tripartite prodrug for

Structure 3 was identified as the new lead from 3-D QSAR studies. Unfortunately, compound 3 suffered from poor water solubility. Propose a tripartite prodrug for 3 that will have enhanced water solubility, include a synthesis for your proposed prodrug and explain how the lead will be released in vivo.

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