Table 20.5 gives data taken from 20 healthy nonsmoking males subjects for one pair of drugs. this is a match pairs design. Numbers 1 to 20 were assigned at random to the subjects. subjects 1 to 10 received the generic drug first, followed by the reference drug first, followed by the generic drug. In all cases, a washout period separated the two drugs so that the first had disappeared from the blood before the subject too the second. By randomizing the order, we eliminate the order in which the drugs were administered from being confounded with the difference in the absorption in the blood. Do the drugs differ significantly in the amount absorbed in the blood?

Subj Ref Generic

15 4108 1755

3 2526 1138

9 2779 1613

13 3852 2254

12 1833 1310

8 2463 2120

18 2059 1851

20 1709 1878

17 1829 1682

2 2594 2613

4 2344 2738

16 1864 2302

6 1022 1284

10 2256 3052

5 938 1287

7 1339 1930

14 1262 1964

11 1438 2549

1 1735 3340

19 1020 3050