The effects of a new drug in cancer patients are being evaluated in a clinic. For this, the salivary flow of patients with head and neck cancer who are starting radiotherapy is compared. The control group receives the placebo while the experimental group receives the new drug. The results are presented in the tables.

Determine if the groups are statistically different at the start of treatment, during the fifth week and during the seventh week. Use the 5 steps learned in class for each comparison. (15 pts.)

b. Determine if any changes occurred between the beginning and end of treatment (7th week) for the control group. Use the 5 steps learned in class. (5 pts.)

c. Determine if any changes occurred between the beginning and end of treatment (7th week) for the experimental group. Use the 5 steps learned in class. (5 pts.)

d. With the information obtained in the previous steps, explain briefly if you understand that the drug had any effect? Justify your answer. (5 pts.)

(Table 4.1 Control Group Patient Start of treatment 5th. week 7th. week)

(Table 4.2 Experimental Group Patient Start of treatment 5th. week 7th. week)

Tabla 4.1 Grupo Control Paciente Inicio del tratamiento Sta. semana 7ma semana 1.005 0.474 0.089 1 2 1.248 1.000 0.911 0.389 0.091 0.035 4 1.391 0.304 0.176 5 0.496 0.311 0.209 6 0.368 0.221 0.191 7 1.772 0.260 0.256 8 1.475 0.457 0.286 9 0.123 0.064 0.059 10 0.918 0.320 0.343 Tabla 4.2 Grupo Experimental Paciente Inicio del tratamiento sta semanal7ma semana 1 0.930 0.822 0.811 2 0.109 0.129 0.438 3 1.918 0.541 1.043 4 1.170 0.749 1.004 5 1.514 0.864 1.307 6 0.727 0.147 0.201 7 0.402 0.427 0.603 8 0.227 0.106 0.532 9 0.386 0.207 0.412 10 0.452 0.130 0.155 Tabla 4.1 Grupo Control Paciente Inicio del tratamiento Sta. semana 7ma semana 1.005 0.474 0.089 1 2 1.248 1.000 0.911 0.389 0.091 0.035 4 1.391 0.304 0.176 5 0.496 0.311 0.209 6 0.368 0.221 0.191 7 1.772 0.260 0.256 8 1.475 0.457 0.286 9 0.123 0.064 0.059 10 0.918 0.320 0.343 Tabla 4.2 Grupo Experimental Paciente Inicio del tratamiento sta semanal7ma semana 1 0.930 0.822 0.811 2 0.109 0.129 0.438 3 1.918 0.541 1.043 4 1.170 0.749 1.004 5 1.514 0.864 1.307 6 0.727 0.147 0.201 7 0.402 0.427 0.603 8 0.227 0.106 0.532 9 0.386 0.207 0.412 10 0.452 0.130 0.155