Question
The enzyme aldolase in glycolysis uses an active site lysine to facilitate a retroaldol condensation reaction and cleave the hexose fructose-1,6-bisphosphate into two trioses. The
The enzyme aldolase in glycolysis uses an active site lysine to facilitate a retroaldol condensation reaction and cleave the hexose fructose-1,6-bisphosphate into two trioses. The enzyme transaldolase (shown below) is involved in the pentose phosphate cycle, which generates the pentose ribose 5-phosphate in the biosynthesis of DNA and RNA. Transaldolase catalyzes a retroaldol, followed by an aldol reaction. Please use your knowledge of the aldolase reaction to propose a mechanism for the shown transaldolase reaction mechanism with arrow pushing.
transaldolase Sedoheptulose 7-phosphate Glyceraldehyde erythrose fructose 4-phosphate 6-phosphate
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