The following data is typical for an adult male subject and should be used to answer the questions below: Compound Px Ux Na+ 150 mEq/L 55 mEq/L Substance Z 1 mg/L 300 mg/L Inulin 4 mg/L 210 mg/L Urine flow rate V& = 0.0025 L/min

D) Compute the rate of Na+ reabsorption?

E) Compute the renal clearance of Substance Z (CZ) and its fractional excretion (FEZ). Explain why it is larger than 1.

F) If the renal venous plasma concentration of Z (Pv,Z) is 0.006 mg/L (essentially = 0), what important renal parameter does CZ approximate?

DEF ONLY no need for ABC

4) The following data is typical for an adult male subject and should be used to answer the questions below: Urine flow rate V=0.0025L/min A) Calculate GFR. B) Calculate the filtration rate for Na+. C) In (B), why could you not use the same formula you used for calculating GFR? Please, limit your answer to a single sentence. D) Compute the rate of Na+reabsorption? E) Compute the renal clearance of Substance Z(CZ) and its fractional excretion (FEZ). Explain why it is larger than 1. F) If the renal venous plasma concentration of Z(Pv,Z) is 0.006mg/L (essentially= 0), what important renal parameter does CZ approximate