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The neurological disorder CANVAS is caused by intronic expansions of the AAGGG repeat in the gene RFC1, which is important for DNA replication. Healthy
The neurological disorder CANVAS is caused by intronic expansions of the AAGGG repeat in the gene RFC1, which is important for DNA replication. Healthy individuals generally have 11 repeats while CANVAS patients can have as many 2000 AAGGG repeats. Tufts' Dr. Sergei Mirkin wants to know if secondary structures are involved in the expansion of these repeats. Which structures should Dr. Mirkin focus his inquiry on? Select all that apply. A-DNA Hairpins Cruciforms Triplex DNA G-quadruplex DNA
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Get StartedRecommended Textbook for
Molecular Cell Biology
Authors: Harvey Lodish, Arnold Berk, Chris A. Kaiser, Monty Krieger, Anthony Bretscher, Hidde Ploegh, Angelika Amon, Matthew P. Scott
7th edition
1464183393, 1464183392, 978-1429234139
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