"This is impossible! Just totally impossible! Ten months ago I was sitting on top of the world. Upper-level management considered me one of the best, if not the best, engineer in the plant. Now look at me! I have bags under my eyes, I haven't slept soundly in the last six months, and here I am, cleaning out my desk. I'm sure glad they gave me back my old job in engineering. I guess I could have saved myself a lot of grief and aggravation had I not accepted the promotion to project manager. The best prepared plans can result in a project failure because of poor execution. Project execution involves the working relationships among the participants and whether or not they support project management. There are two critical working relationships: the project-line manager interface and the project-executive management interface. There are other factors that can affect the execution of a project. These include open communications, honesty, and integrity in dealing with customers, truth in negotiations, and factual status reporting. Execution can also be influenced by the quality of the original project plan. A project plan based on faulty or erroneous assumptions can destroy morale and impact execution.

101 I'd like to know the possibility of giving these drugs in epileptics: vincamine (Oxicebral), cinnarizine, piribedil (Trivastal) and pentoxyphylline (Trental). I'd like to know if they are contraindicated.

102 If an epileptic patient, treated with oxcarbazepine, develops a rash, should this drug be withdrawn or the dosage decreased and then increased gradually again?

103 Does a patient with refractory epilepsy benefit from acetazolamide?

104 What anti-epileptic drug is recommended for a child with epilepsy and co-morbid attention deficit hyperactivity disorder (ADHD)? Can Ritalin safely be used for treatment?

105 What is the difference in efficacy and pharmacokinetics between sodium valproate and valproic acid?

106 Is it safe to give valproic acid to infants below 12 months of age?

107 How many times must the liver transaminases (SGOT and SGPT) rise to justify a discontinuation of valproic acid therapy in children? Which of these enzymes is more sensitive and reliable in this situation?

108 1. Does valproic acid block the photosensitivity phenomenon in reflex epilepsy? 2. Can a patient with this photosensitivity be safely exposed to computer games or other photic stimuli when receiving valproic acid treatment? 3. Does the photosensitivity phenomenon occur in partial seizures?

109 1. Can an epileptic fit be induced in idiopathic and symptomatic focal epilepsy syndromes by flickering lights? 2. Is valproate effective against the photosensitive phenomenon (seizure induction by flickering light)?

110 How much time should one give before a loading dose of phenytoin is judged to be ineffective in controlling seizures and an alternative should be instituted?