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1 Please could you tell me the normal range of values for the liver function test serum alkaline phosphatase. The only mention of the parameters is that a reading of 1000 serious liver condition.

2 What is the best single test of liver function to exclude liver cell failure in the routine work-up of a patient with early dementia?

3 How valuable is the measurement of the liver span in a physical examination?

4 Why has the term 'chronic liver disease' replaced terms such as 'chronic hepatitis'? What exactly does this new term mean and what conditions does it cover?

5 Can jaundice occur early in schistosomal hepatic fibrosis and, if so, how?

6 My patient has been found to have a serum bilirubin of 34 mol/L (2 mg/dL) on three occasions. The other liver tests are normal. He tells me he has Gilbert's disease; how can I prove this?

7 Why is urinary urobilinogen increased in haemolytic jaundice? If the bilirubin in this condition is unconjugated, how does it reach the terminal ileum to be converted into urobilinogen

8 How does cholestatic jaundice affect the kidney?

9 What is the mechanism by which cholestatic jaundice causes bradycardia?

10 Are 'jaundice' and 'icterus' one and the same? I was taught that icterus is yellowing of the sclera, while jaundice is yellowing of the skin and the mucous membranes. As a result, carotenaemia can produce jaundice but not icterus: is this so? I would be grateful if you would clarify this for me.