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What must investigators do prior to making any significant changes in their use of animals? Modify the animal protocol form and keep a copy for

What must investigators do prior to making any significant changes in their use of animals?

Modify the animal protocol form and keep a copy for their files.

Obtain approval of the animal husbandry staff.

Conduct a quick pilot study to be sure the change is useful.

Obtain IACUC approval.

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