Question
X is a drug used in the treatment of cancer (20% metabolized and 80% renally excreted). The following data was obtained from a constant intravenous
X is a drug used in the treatment of cancer (20% metabolized and 80% renally excreted). The following data was obtained from a constant intravenous infusion dose of 10 mg/kg/h for six hours for a person that weighed 60 kg. Use the 6hr value as Css to answer the questions below.
Time(hr) | Plasma Conc.(mg/L) |
0 | 0 |
0.25 | 4.4 |
0.5 | 8 |
0.75 | 11 |
1 | 13 |
2 | 20 |
3 | 23 |
6 | 25 |
a)From the data above, what is the k value in h-1.
b)What is the half-life, t1/2, in hours.
c)What is the volume of distribution, V, in liters.
d)What is the clearance, Cl, in L/h.
e)You want to maintain a plasma concentration of 35 mg/L. Estimate the infusion rate (in mg/h) necessary to maintain the plasma concentration of 35 mg/L.
f)Suggest a loading dose (in mg) for the patient which would give you Css of 35 mg/L immediately.
e)How long will it take (in hours) to reach 94% of steady state?
g)Find the plasma concentration (in mg/L) 3 hours after infusion is discontinued (from the given data).
Show all your work.
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