X is a drug used in the treatment of cancer (20% metabolized and 80% renally excreted). The following data was obtained from a constant intravenous infusion dose of 10 mg/kg/h for six hours for a person that weighed 60 kg. Use the 6hr value as Css to answer the questions below.

Time(hr)	Plasma Conc.(mg/L)
0	0
0.25	4.4
0.5	8
0.75	11
1	13
2	20
3	23
6	25

a)From the data above, what is the k value in h-1.

b)What is the half-life, t1/2, in hours.

c)What is the volume of distribution, V, in liters.

d)What is the clearance, Cl, in L/h.

e)You want to maintain a plasma concentration of 35 mg/L. Estimate the infusion rate (in mg/h) necessary to maintain the plasma concentration of 35 mg/L.

f)Suggest a loading dose (in mg) for the patient which would give you Css of 35 mg/L immediately.

e)How long will it take (in hours) to reach 94% of steady state?

g)Find the plasma concentration (in mg/L) 3 hours after infusion is discontinued (from the given data).

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