Warfarin (coumadin) binds to human plasma albumin to prevent blood clotting in the reaction Measured thermodynamic values
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Warfarin (coumadin) binds to human plasma albumin to prevent blood clotting in the reaction
Measured thermodynamic values for this reaction at 25οC are ΔG =30.8 kJ/mol, ΔH = 13.1 kJ/mol, and
(a) Determine the entropy change for this reaction at 25οC.
(b) Determine the fraction of unbound albumin over a temperature range of 0 to 50οC for a solution initially containing warfarin and albumin at 0.1 mM.
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Related Book For
Separation Process Principles Chemical And Biochemical Principles
ISBN: 9780470481837
3rd Edition
Authors: By J. D. Seader, Ernest J. Henley, D. Keith Roper
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