What is responsible for the large range in values of dissociation constants listed in Table 2.18? Table

What is responsible for the large range in values of dissociation constants listed in Table 2.18?

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Table 2.18 Dissociation Constants of Some Bioaffinity Interactions Ligand-Receptor Pair Enzyme-substrate Lectin-monosaccharide Lectin-oligosaccharide Antibody-antigen DNA-protein Cell receptor-ligand Avidin/Streptavidin-biotin KD (M) 10-³-10-5 10-³-10-5 10-5-10-7 10-7-10-11 10-8-10-⁹ 10-⁹-10-12 ~10-15