Which of the following mutations affecting proteins involved in the intracellular signaling pathway that is activated by

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Which of the following mutations affecting proteins involved in the intracellular signaling pathway that is activated by epidermal growth factor (EGF) would you expect to promote cancer?

A. A mutation that prevents GTP from binding to Ras 

B. A mutation that keeps MAPK active for a longer period of time than normal 

C. A mutation that prevents the dephosphorylation of the EGF receptor.

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