In nucleophilic aromatic substitution reactions that proceed by the addition elimination mechanism, fluorine is the most
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In nucleophilic aromatic substitution reactions that proceed by the addition – elimination mechanism, fluorine is the most easily replaced halogen in spite of the fact that F- is by far the worst leaving group among halide ions. For example, 1-fluoro-2,4-dinitrobenzene reacts much more rapidly with amines than does the corresponding chloro compound. Suggest an explanation.
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Organic Chemistry structure and function
ISBN: 978-1429204941
6th edition
Authors: K. Peter C. Vollhardt, Neil E. Schore
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