Secreted by the pituitary gland, corticotropin is a hormone that stimulates the adrenal cortex. Determine its primary

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Secreted by the pituitary gland, corticotropin is a hormone that stimulates the adrenal cortex. Determine its primary structure from the following information. 

(i) Hydrolysis by chymotrypsin produces six peptides: Arg-Trp, Ser-Tyr, Pro-Leu-Glu-Phe, Ser-Met-Glu-His-Phe, Pro-Asp-AlaGly-Glu-Asp-Gln-Ser-Ala-Glu-Ala-Phe, and Gly-Lys-Pro-Val-Gly-Lys-Lys-Arg-Arg-Pro-ValLys-Val-Tyr. 

(ii) Hydrolysis by trypsin produces free lysine, free arginine, and the following five peptides: Trp-Gly-Lys, Pro-Val-Lys, Pro-Val-Gly-Lys, Ser-Tyr-Ser-Met-Glu-His-Phe-Arg, and Val-Tyr-Pro-Asp-Ala-Gly-Glu-Asp-Gln-Ser-Ala-Glu-Ala-Phe-Pro-Leu-Glu-Phe.

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Organic Chemistry structure and function

ISBN: 978-1429204941

6th edition

Authors: K. Peter C. Vollhardt, Neil E. Schore

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