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Chemistry And Pharmacology Of Drug Discovery(1st Edition)
Authors:
Jie Jack Li
Cover Type:Hardcover
Condition:Used
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Book details
ISBN: 1394225121, 978-1394225125
Book publisher: Wiley
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Book Summary: Case Studies Of 20 Successful FDA-approved Drugs, From Biological Rationale To Clinical Efficacy Studies And State-of-the-art ApplicationsChemistry And Pharmacology Of Drug Discovery Illustrates How Chemistry, Biology, Pharmacokinetics, And A Host Of Disciplines Come Together To Produce Successful Medicines, Discussing A Total Of 20 Drugs That Are All FDA-approved Post 2021?some Of Which Are First-in-class And Revolutionary. The Four Sections In This Book Cover Infectious Disease, Cancer Drugs, CNS Drugs, And Miscellaneous Drugs. Each Chapter Covers Background Material On The Drug Class And/or Disease Indication And Key Aspects Relevant To The Discovery Of The Drug, Including Structure-activity Relationships, Pharmacokinetics, Drug Metabolism, Efficacy, And Safety. This Book Is Contributed To By Various Veterans And Well-known Experts In Medical Chemistry, Many Of Whom Discovered The Drugs They Reviewed, Leading To Tremendous Quality And Depth Of Insight. Some Of The Drugs Covered In Chemistry And Pharmacology Of Drug Discovery Include: Nirmatrelvir (Paxlovid With Ritonavir), A 3-chymotrypsin-like Protease Inhibitor For Treating SARS-CoV-2 InfectionDoravirine (Pifeltro), A Third-generation Non-nucleoside Reverse Transcriptase Inhibitor For The Treatment Of HIV-1 InfectionOteseconazole (Vivjoa), A CYP51 Inhibitor For Treating Recurrent Vulvovaginal Candidiasis, And Rimegepant (Nurtec ODT), A CGRP Antagonist For Treating MigraineCiprofol (Cipepofol), A ?-Aminobutyric Acid Receptor Agonist For Induction Of Anesthesia, And Ozanimod (Zeposia), An S1P Receptor Antagonist For Treating Multiple SclerosisDeucravacitinib (Sotyktu), A First-in-class Deuterated TYK2 Inhibitor For The Treatment Of Plaque PsoriasisChemistry And Pharmacology Of Drug Discovery Serves As An Excellent And Highly Authoritative Learning Resource For Medicinal, Organic, Synthetic, And Process Chemists As Well As Research Scientists In Lead Optimization And Process Development.
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