The glycine cleavage system is a group of four enzymes that together catalyze the following reaction:

Use the following information to determine the sequence of reactions involved in the glycine cleavage system:
a. The first enzyme involved in the reaction is a PLP-requiring decarboxylase.
b. The second enzyme is aminomethyltransferase. This enzyme has a lipoate coenzyme.
c. The third enzyme is an N5, N10 -methylene-THF synthesizing enzyme. It catalyzes a reaction that forms as one of the products.
d. The fourth enzyme is an FAD-requiring enzyme.
e. The cleavage system also requires NAD+

Transcribed Image Text:

glycine cleavage systemN N0-methylene-THF + CO