The oxidation of a DNA-guanine residue to 8-oxoguanine (8-oxoG) is mutagenic, because 8-oxoG pairs readily with adenine

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The oxidation of a DNA-guanine residue to 8-oxoguanine (8-oxoG) is mutagenic, because 8-oxoG pairs readily with adenine in the next round of replication. Show a pathway beginning with the oxidation of G in a G-C base pair and leading to a mutant base pair, and identify the products of each round of replication.
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Biochemistry Concepts and Connections

ISBN: 978-0321839923

1st edition

Authors: Dean R. Appling, Spencer J. Anthony Cahill, Christopher K. Mathews

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