When the (R, R) isomer of the amine shown is treated with an excess of methyl iodide,
Question:
(a) Draw the structure of the major (Hofmann) product.
(b) Some Zaitsev product is also formed. It has the (E) configuration. When the same amine is treated with MCPBA and heated, the Zaitsev product has the (Z) configuration. Use stereochemical drawings of the transition states to explain these observations.
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The key to this problem is to understand that Hofmann elimination occ...View the full answer
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