Consider the following solid-phase peptide synthesis: (a) Give the structure of each compound A-P. (b) Explain the

Question:

Consider the following solid-phase peptide synthesis:

(a) Give the structure of each compound A-P.
(b) Explain the reason for the Boc group on the side chain of the Lys group in the reaction B †’ C
(c) Explain why Boc-Val rather than Fmoc-Val is used in the D †’ E step of the synthesis.

Fantastic news! We've Found the answer you've been seeking!

Step by Step Answer:

Related Book For book-img-for-question

Organic Chemistry

ISBN: 978-0981519432

5th edition

Authors: Marc Loudon

See More Books

Question Posted: Apr 26, 2016 09:25 AM

See More Questions

Identify the following two isomeric alkyl halides (C5H11Br) from their 300-MHz NMR spectra, which are as follows: Compound A: 0.91 (6/7, d, J = 6 Hz); 1.7-1.8 (3H, complex); 3.42 (2H, t, J = 6 Hz)...
The polymeric resin used for Merrifield solid-phase peptide synthesis (Section 26.8) is prepared by treating polystyrene with N-(hydroxymethyl) phthalimide and trifluoromethanesulfonic acid, followed...
Sometimes it is necessary in solid-phase peptide synthesis to use a resin linker that is more sensitive (that is, more reactive) to acid than the linker shown in Eq. 26.21 on p. 1285. The following...
Laverty Clinic plans to purchase a new centrifuge machine for its New York facility. The machine costs $94,000 and is expected to have a useful life of 6 years, with a terminal disposal value of...
How does Nationalism impact the causes of the First World War from a global perspective?
Extract the annual report of a Fortune Global 500 company from a country different from your home country; use the site www.glgc.com/g600.html, or...
Suppose an experiment utilizing a randomized block design has four treatments and nine blocks, for a total of 4 * 9 = 36 observations. Assume that the total sum of squares for the response is...
A technician services mailing machines at companies in the Phoenix area. Depending on the type of malfunction, the service call can take 1, 2, 3, or 4 hours. The different types of malfunctions occur...
Home Retail Industrial Total Sales $552300 $322300 $832300 $1706900 Variable costs 359500 220000 683000 1262500 192800 102300 149300 444400 Contribution margin Fixed costs 127300 132300 117300 376900...
A CCPC disposes of a building used for business operations with capital cost of $1 million and UCC of $400,000, for $1.25 million. Given this information only, indicate the dollar changes to the...
After the coupling, he deprotects his resin-bound peptide with 20% piperidine in DMF, and then completes the synthesis in the usual way by coupling Fmoc-Gly, deprotecting the peptide, and removing it...
What other pair of amino acids are not differentiated by amino acid analysis?
Serene Comfort sells a wide range of mattresses, beds, and other bedroom furniture. For the most recent year, they provide the following data: Beginning inventory .... $2,450,000 Cost of purchases...
5. Consider the classes below and determine what is printed out by the client code. public class V { public void one(){ System.out.print("it"); } public void two(){ System.out.print("go"); } } public...
Consider the following closed economy short-run IS-LM model with income taxation. The economy is described by equations (1) through (6): (1) C = 200 + 0.8(Y -T); (2) T = 800+0.25Y;(3) G = 500; (4) 1...
(30 pts) A binary search tree is given, write a method to delete a node from the tree. Assume the successor and predecessor methods are provided, partial code is provided below. Finish the reset of...
Reminder: Formatting is always important in your code (comments, indentation, variable names, etc.) And please always start your Java code file with a multi-line comment listing the name of the...
An element is the majority of a size-n array A [1...n] if it occurs more than 1 times in the array. Design a O(log n) time algorithm to find the majority of A in the EREW PRAM model using n...
Describe the steps needed to write balanced equations.
SCHEDULE OF COST OF GOODS MANUFACTURED The following information is supplied for Sanchez Welding and Manufacturing Company. Prepare a schedule of cost of goods manufactured for the year ended...
Provide a mechanism for the following reaction. H2SO H2O
The widely used antioxidant and food preservative called BHA (butylated hydroxyanisole) is actually a mixture of 2-tert-butyl-4-methoxyphenol and 3-tert-butyl-4-methoxyphenol. BHA is synthesized from...
Provide a mechanism for the following reaction. NO2 SO NaOCH OH NO2 NO2
Your company BMG Inc. has to liquidate some equipment that is being replaced. The originally cost of the equipment is $120,000. The firm has deprecated 65% of the original cost. The salvage value of...
1. What are the steps that the company has to do in time of merger transaction? And What are the obstacle that may lead to merger failure? 2.What are the Exceptions to not to consolidate the...
Problem 12-22 Net Present Value Analysis [LO12-2] The Sweetwater Candy Company would like to buy a new machine that would automatically "dip" chocolates. The dipping operation currently is done...

Consider the following solid-phase peptide synthesis: (a) Give the structure of each compound A-P. (b) Explain the

Question:

solid phase; structure in Eq. 26.21, p. 1285 20% piperidine DMF FmocNHCH2C Cs CICH FmocNHCHCO2H (CH24 NHBoc 20% piperidine Boc-Val E DCC/NHS α-Fmoc-e-Boc-Lys DCC/NHS CFCO2H _encoln, Peptide p

Step by Step Answer:

a Compound A results from the SN2 coupling reaction to the resin analogous to Eq 2622 on text p 1285 ...View the full answer

Organic Chemistry

Students also viewed these Organic Chemistry questions