Studies on cAMP actions in cultured cells usually involve adding to the cell culture not cAMP, but dibutyryl cAMP (see structure) Why is this structural modi iuml not cation necessary How could you test the premise that di Bu cAMP has the same biochemical e iuml not ects as cAMP 0 Na Dibutyryl cAMP...

Negative charge on the phosphate of cAMP prevents its pa ...

Studies on cAMP actions in cultured cells usually involve adding to the cell culture not cAMP, but

Question:

Studies on cAMP actions in cultured cells usually involve adding to the cell culture not cAMP, but dibutyryl cAMP (see structure). Why is this structural modiï¬cation necessary? How could you test the premise that di-Bu-cAMP has the same biochemical eï¬€ects as cAMP?