Oxidation of DNA bases is mutagenic. An oxidized form of guanine, 8-oxoguanine, can base-pair with adenine, leading
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Oxidation of DNA bases is mutagenic. An oxidized form of guanine, 8-oxoguanine, can base-pair with adenine, leading to errors in DNA replication. A gene called mutT acts to minimize the tendency of A-oxoG base pairs to form. The mutT gene product was purified and shown to be an enzyme. Speculate on the reaction catalyzed by this enzyme.
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The enzyme encoded by the mutT gene is called MutT MutT is responsible for minimizing the mutagenic ...View the full answer
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Related Book For 
Biochemistry Concepts And Connections
ISBN: 9780134641621
2nd Edition
Authors: Dean Appling, Spencer Anthony-Cahill, Christopher Mathews
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