10.127 [EX10-127] A constant objective in the manufacture of contact lenses is to improve the level and variation for those features that affect lens power and visual acuity. One such feature involves the tooling from which lenses are ultimately manufactured.

The results of two initial process development runs were examined for Critical Feature A. Two distinct product lots were manufactured with slight differences designed to affect the feature in question. Each lot was then sampled. Lot 1 had a smaller run time than Lot 2, and therefore more samples were taken for Lot 2.

a. Calculate the mean and standard deviation of Critical Feature A for Lots 1 and 2.

b. Is there evidence of a difference in the variability of Critical Feature A between Lots 1 and 2? Use an alpha value of 5% to make a determination.

c. Is there evidence of a difference in the mean levels of Critical Feature A between Lots 1 and 2. Use an alpha value of 5% to make a determination.

Transcribed Image Text:

Lot 1 Critical Lot 2 Critical Lot 2 Critical Sample Feature A Sample Feature A Sample Feature A 1 0.017 - 1 0.026 14 2 0.021 2 0.027 15 15 0.041 0.021 3 0.006 3 0.024 16 0.022 45678 0.009 4 0.023 17 0.027 0.018 5 0.034 18 0.032 0.021 6 0.035 19 0.023 0.013 7 0.035 20 0.023 0.017 8 0.033 21 0.024 9 0.034 22 0.017 10 0.033 11 0.032 12 0.038 222 23 0.023 24 0.019 25 0.027 13 0.041