Treating Chronic Fatigue Syndrome Patients with chronic fatigue syndrome were tested, then retested after being treated with fludrocortisone. Listed below are the changes in fatigue after the treatment (based on data from “The Relationship Between Neurally Mediated Hypotension and the Chronic Fatigue Syndrome” by BouHolaigah, Rowe, Kan, and Calkins, Journal of the American Medical Association, Vol. 274, No. 12). A standard scale from 27 to 17 was used, with positive values representing improvements. Use a 0.01 significance level to test the claim that the mean change is positive. Does the treatment appear to be effective?

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