Intestinal bacteria convert choline to trimethylamine, and the liver converts this gas to trimethylamine N-oxide (TMAO). TMAO
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Intestinal bacteria convert choline to trimethylamine, and the liver converts this gas to trimethylamine N-oxide (TMAO). TMAO promotes atherosclerosis, possibly by stimulating macrophages to take up LDL.
(a) Could this chemistry explain why eating large amounts of eggs (which are rich in phosphatidylcholine) is a risk factor for cardiovascular disease?
(b) Some research suggests that ingesting supplemental phosphatidylcholine can slow the aging process. Is this consistent with your answer to Part (a)?
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Related Book For
Fundamentals Of Biochemistry Life At The Molecular Level
ISBN: 9781118918401
5th Edition
Authors: Donald Voet, Judith G Voet, Charlotte W Pratt
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