Mouse embryonic stem cells produce high levels of threonine dehydrogenase, whose activity appears to be essential for

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Mouse embryonic stem cells produce high levels of threonine dehydrogenase, whose activity appears to be essential for maintaining high levels of S-adenosylmethionine. Explain the link between threonine metabolism and SAM production.

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The link between threonine metabolism and Sadenosylmethionine SAM production involves a series of biochemical reactions within the cell Threonine is an essential amino acid that serves as a precursor for various important metabolic pathways including the synthesis of SAM Heres how threonine metabolism is connected to SAM production Threonine Degradation Threonine is catabolized in cells through a series of enzymatic reactions One of the key enzymes involved in threonine degradation is threonine dehydrogenase Threonine dehydrogenase converts threonine into 2amino3ketobutyrate AKB in a reaction that involves the removal of an amino group from threonine Threonine 2Amino3ketobutyrate AKB Conversion of AKB to Methionine AKB is further metabolized in a series of steps to produce methionine another amino acid Methionine is a ...View the full answer

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