4. Pain is sensed by free nerve endings called nociceptors. Ascending pain fibers synapse in the substantia

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4. Pain is sensed by free nerve endings called nociceptors. Ascending pain fibers synapse in the substantia gelatinosa, the thalamus, and the anterior cingulate and somatosensory cortices. Descending information regarding pain is transmitted to the periaqueductal gray (PAG). (LO4)

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