Vanadium(IV) complexes act as mimics for insulin, a hormone secreted by the pancreas. Among the complexes being studied is [VOL₂] in which HL is maltol:

Figure 21.45 shows the pH dependence of the species in aqueous solution containing [VO]²⁺ and HL in a 1 : 2 ratio. 

(a) Suggest a structure for [VOL₂]. 

(b) For which ion is [VO]²⁺ an abbreviation? 

(c) Rationalize the shapes of the curves in Fig. 21.45 and suggest structures for the species present. 

(d) Why are studies such as that summarized in Fig. 21.45 important in the development of anti-diabetes drugs?

Figure 21.45.

Transcribed Image Text:

0 maltol OH