Nonsteroidal anti-inflammatory drugs, often referred to as NSAIDs, are commonly used to treat minor aches and pains. Four of the most common NSAIDs are:

(a) How many sp³-hybridized carbons are present in aspirin?

(b) How many sp²-hybridized carbons are present in naproxen?

(c) What is the molecular formula of acetaminophen?

(d) Aspirin, ibuprofen, and naproxen are all believed to target the same enzyme, cyclooxygenase, which produces substances called prostaglandins, that mediate inflammation. Discuss any similarities in the structures of these drugs.

Transcribed Image Text:

H3C H H Н Н Н Acetylsalicylic acid (aspirin) Н С- H -CH3 C С OH H Naproxen (Naprosyn, Aleve) H CH3 OH H3C н нн H CH3 Н. H H3C C Н N Ibuprofen (Advil, Nuprin, Motrin) Н U H Н CH3 Н Acetaminophen (Tylenol) OH Н OH