(a) Draw a resonance structure for the carbocation intermediate in Eq. 27.48. (b) All of the enzyme-catalyzed...
Question:
(a) Draw a resonance structure for the carbocation intermediate in Eq. 27.48.
(b) All of the enzyme-catalyzed glycosylations require Mn2+, a divalent cation. Suggest a role for the metal ion in the glycosylation mechanism.
Transcribed Image Text:
HO HO HÖ H protein CH₂OH 0=C R LH NH NH | :0 CH3 O protein H UDP SN1 HO HO CH₂OH O=C NH CH3 + Ö—UDP a resonance-stabilized carbocation H (upper face is blocked by the enzyme) HO H protein R LH NH 0 protein HO HO CH₂OH proton transfer to H₂O NH H3C R O H H H protein NH + H₂0* protein (27.48)
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