Aspartic acid and glutamic acid are the two naturally occurring a-amino acids that have carboxylate groups in
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Aspartic acid and glutamic acid are the two naturally occurring a-amino acids that have carboxylate groups in their side chains. Asparagine and glutamine are the corresponding a-amino acids in which the side chains are primary amides. (All of these amino acids have the S configuration.)
Asparagine synthetase catalyzes the biosynthesis of asparagine from glutamine according to the equation shown in Fig. P25.40. Note that the amide —NH2 group in asparagine comes from the amide —NH2 group of glutamine.
Transcribed Image Text:
H NH3 C-CH₂ C-O T CO₂ nar aspartic acid NH3 C-CH₂CH₂-C-O T CO₂ glutamic acid H + NH3 –CH,-C-NH, CR H™ | CO₂ + NH3 asparagine C–CH,CH-C—NH, 1 CO₂ glutamine
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a In the first step aspartic acid is adenylated by ATP as illustrated by Eq 2525c on text p 1308 NH NH3 fate fotoges CCH 0CH H CO aspartic acid HO NH3 ...View the full answer
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