The enzyme catalyzed formation of fatty acyl carnitine from fatty acyl CoA (Fig P25 36) is an early step in the metabolism of fatty acids The G for the hydrolysis of an acyl CoA is 231 4 kJ mol 1 (7 5 kcal mol 1 ), and the G for the hydrolysis of an acyl carnitine is 17 4 kJ mol 1 (4 2 kcal mol 1 )...

a Use a strategy similar to the one shown in the solution to problem 2517a in this manu ...

The enzyme-catalyzed formation of fatty acyl-carnitine from fatty acyl-CoA (Fig. P25.36) is an early step in the

Question:

The enzyme-catalyzed formation of fatty acyl-carnitine from fatty acyl-CoA (Fig. P25.36) is an early step in the metabolism of fatty acids. The ΔG°´ for the hydrolysis of an acyl-CoA is 231.4 kJ mol^–1 (–7.5 kcal mol^–1), and the ΔG°´ for the hydrolysis of an acyl-carnitine is –17.4 kJ mol^–1 (–4.2 kcal mol^–1).

(a) Calculate the ΔG°´ for the reaction shown in Fig. P25.36.

(b) Calculate the equilibrium constant (at pH = 7) for this reaction at 37 °C (310 K).

(c) Give a structural reason that the reaction is so favorable. -SCOA + a fatty acyl-CoA Figure P25.36 HO H (CH3)3NCH CH,COz carnitine carnitine acyltransferase. (CH3)3NCH