In repeated attempts to synthesize the dipeptide Val-Leu, aspiring peptide chemist Polly Styreen performs each of the
Question:
In repeated attempts to synthesize the dipeptide Val-Leu, aspiring peptide chemist Polly Styreen performs each of the following operations. Explain what, if anything, is wrong with each procedure.
(a) The cesium salt of leucine is allowed to react with chloromethyl resin. The resulting derivative is treated with Fmoc-Val and DIC/HOBt, then with trifluoroacetic acid.
(b) The cesium salt of Fmoc-Leu is allowed to react with the chloromethyl resin. The resulting derivative is then treated with Fmoc-Val and DIC/HOBt, then with trifluoroacetic acid.
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a Because the amino group of leucine is not protected a certain amount maybe most of attachment ...View the full answer
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