1. Case Studies /Team based discussion on Adrenergic Drugs Case 1 MR is a 26-year-old man who weighs 190Kg. He has sought counseling for weight loss, but modifications of diet and exercise alone have never really been successful for him. He recently watched a "20/20" program (aired 2/3/95) that described the use of prescription drugs as part of a weight loss program. The drug therapy used a combination of fenfluramine (figure 1) and phentermine (figure 2). 1. Explain the mechanism of action of EACH drug (including a brief structure-activity relationship). 2. Would the addition of a -hydroxyl group to either of these drugs improve CIS penetration? Why, or why not? 3. what do you think of giving Norepinephrine (NE) as a medication for this type of therapeutic intervention