Which of the following is true about the mutation that causes sickle cell anemia? a. The sickle cell mutation disrupts the formation of quaternary structure of hemoglobin. b. The sickle cell mutation provides resistance to severe malaria because it causes reduced oxygen binding. c. Sickle Cell Anemia can be caused by a mutation from Glutamic Acid to Valine. d. The sickle cell mutation causes hydrophilic residues on the surface of hemoglobin to aggregate. One of the features of some neurodegenerative disorders as Alzheimer's disease is the formation of protein aggregates. All of the following are true of the protein aggregates EXCEPT: a. The proteins that make the aggregates have cellular functions when not misfolded. b. The proteins that form aggregates are induced to change their folding by other misfolded proteins. c. Hydrophobic residues are the primary cause of misfolding. d. The proteins that form aggregates have altered folding.