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4) Polymorph screening of a given API showed the existence of two Polymorphs (Form 1 and Form 2). The solubility of these two polymorphs in
4) Polymorph screening of a given API showed the existence of two Polymorphs (Form 1 and Form 2). The solubility of these two polymorphs in acetone can be represented by the following relationship: Form 1: Ceq=12e0.05T Form 2: Ceq=3e0.075T where the temperature T is given in Celsius and the solubility Ceq is in mg/ml. a. In the same graph, plot the solubilities for both polymorphs. Do not sketch, plot using a graphing program. For your plot choose a temperature range that could reasonably be used for a pharmaceutical crystallization. b. Determine the transition temperature between Form 1 and Form 2. c. Based on your graph and the notes from the class, design a crystallization process for this API. Explain what type of crystallization (cooling, anti-solvent or evaporative) you would use in your process and give reasons for your
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