44. Which of the following is a poor surface anaesthetic ?
(a) Procaine
(b) Lidocaine
(c) Tetracaine
(d) Benoxinate

45. The local anaesthetic having high cardiotoxic and arrhythmogenic potential is
(a) Lidocaine
(b) Procaine
(c) Bupivacine
(d) Chloroprocaine

46. Which of the following is a sign of deep anaesthesia ?
(a) Appearance of tears in eyes
(b) Resistane to passive inflation of lungs
(c) Fall in blood pressure
(d) Patient makes swallowing movements

47. Which inhalational general anaesthetic is metabolized in the body to a significant extent
(a) Sevoflurane
(b) Isoflurane
(c) Ether
(d) Halothane

48. Binding of Diazepam with acetylcholine muscarinic receptors results in?
a) agonizing effect on muscarinic receptors
b) Antagonizing effect on muscarinic receptors
c) Do not produce any significant effect
d) Do not bind with muscarinic receptor

49. Therapeutic use of drug Diazepam is/are?
a) Treatment of Acute alcohol withdrawal
b) Treatment of seizures
c) Treatment of anxiety
d) All of the above

50. Which amongst the following are the correct statements with respect to the SAR of drug
Diazepam?
I. Ring A should include an aromatic or heteroaromatic ring for binding with 5-phenyl-1,4-  benzodiazepin-2-one derivatives.
II. An electronegative group at 7-position of the ring A increases the functional anxiolytic  activity.
III. Substitutions at 6, 8 or 9 position with electronegative group on ring A will decrease the  functional anxiolytic activity.
IV. When Heterocycles used as ring A, drug shows poor pharmacological activity.
a) I, IV
b) I, II, IV
c) I, II, III, IV
d) II, III, IV