A 50 kg human is given an IV dose of 800 mg (16 mg/kg) of a chemical, and the plasma concentration of the chemical is plotted vs. time in the figures below.

What is the concentration of the chemical at time zero?

2) What is the volume of distribution (V_d) of the chemical in L/kg body weight and what does it mean?

16 8H Plasma drug concentration (mg/L) 4 2H 1 2 10 2 10 4 6 8 Time (hours) 4 6 8 Time (hours)