a Pom121 0.2 T- Single exponential decay 0.14 - Residuals -0.1+ -0.2 3 6 9 12 15 Time (hours) b Nup50 0.2 T- 0.21 Single exponential decay Bi-exponential decay 0.1 0.1 Residuals Residuals 0.1 -0.1+ -0.2 -0.2 60 120 240 300 120 180 240 300 180 60 Time (seconds) Time (seconds) c Nup62 0.21 0.21 Single exponential decay Bi-exponential decay 0.1 0.1 Residuals Residuals 0 -0.1 -0.1 -0.21 -0.2- 15 3 15 3 12 6 12 0