A study is designed to investigate whether there is a difference in response to various treatments in patients with Rheumatoid arthritis. The outcome is the patient's self-reported effect of treatment. The data are shown below. Is there a significant difference in the effect of treatment? Run the test at a 5% level of significance.

Symptoms Worsened No Effect Symptoms Improved Total

Treatment 1 22 14 14 50

Treatment 2 14 15 21 50

Treatment 3 9 12 29 50

Please provide answer and explanation.