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The schematic of the Michaelis-Menten kinetics of an enzyme is shown below. Which of these steps is the rate-determining step? k enzyme E substrate S enzyme-substrate complex ES product P + O A.K1 + k2 - Combination of ES and EP O B.The rate is always the same, regardless of E, S or P. O C.K_1 - The dissociation of the ES complex O D.K1 - The formation of the ES complex D. E. K2 - The formation of the product (E + P)