In what ways do you think the "6Is of the e-marketing mix" framework can be leveraged by marketers to gain a competitive advantage in the digital landscape? Which of the six key areas do you think are most important and why? Please provide specific examples to support your arguments and insights. Additionally, consider how the digital marketing landscape has evolved since McDonald and Wilson's original framework was introduced in 1999 and how this may impact the relevance and applicability of the "6Is" today.