Problem 5: The rate and time of dissolution of a drug are important pharmacological parameters, 75 mg of fairly uniform-sized particles (diameter = 150 m) of the drug tolbutamide was added to 1000 ml water in a stirred vessel to conduct a dissolution experiment. The amount dissolved was determined by analyzing the samples withdrawn from time to time and the results are in the table below Determine the "dissolution rate constant" where kiC; k' (see Martin, A., Physical Pharmacy, 4th edition, 2001) under the prevailing conditions. dops Here, k = dissolution mass transfer coefficient, m/s Cg = solubility of the drug in water (kg/m3) dp = initial diameter in meters Ps = density of solid in kg/m3 Time (min) 0 Solute Concentration (mg/mL) 0 10 20 30 40 50 0.0197 0.0374 0.0510 0.0595 0.0650