question 3

(Questions 1-3) Immediate release medications quickly deliver their drug content with the maximum concentration reached in a short time; sustained-release medications, on the other hand, take longer to reach maximum concentration. As part of a study, immediate release codeine (IRC) was compared with sustained release codeine (SRC) using 82 health patients. The patients were randomly assigned to one of the two types of codeine and treated for 2.5 days; after a 7-day washout period each patient was given the other type of codeine. Thus, each patient received both types. The average difference for patients between the sustained release codeine (SRC) and immediate release codeine (IRC) concentrations was 60.1 ng-mL/hr (calculated as SRC-IRC) with a standard deviation of 290.5 ng-mL/hr. Conduct the appropriate test to determine if the SRC concentration differs from the IRC on average. Use a t-critical of 1.99. 1. What is the alternate hypothesis for this test? 2. What is the test statistic value? 3. What is your conclusion