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Write a brief methodology for the article listed below. A comprehensive experiment is not required but must discuss the key concepts of medicinal chemistry involved.

Write a brief methodology for the article listed below. A comprehensive experiment is not required but must discuss the key concepts of medicinal chemistry involved. 

"6-Thioguanosine Monophosphate Prodrugs Display Enhanced Performance against Thiopurine-Resistant Leukemia and Breast Cancer Cells"

Reference: 

6-Thioguanosine Monophosphate Prodrugs Display Enhanced Performance against Thiopurine-Resistant Leukemia and Breast Cancer Cells Moreno S, et al., Journal of Medicinal Chemistry 2022 65 (22), 15165-15173 DOI: 10.1021/acs.jmedchem.2c01010

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