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You aim to achieve a steady 1 0 n M plasm concentration of a 7 5 kDa protein. What dosing strategy should you use to
You aim to achieve a steady plasm concentration of a kDa protein. What dosing strategy should you use to administer the molecule? You have the following data from pilot experiments: a tracer dose of protein yields an area under the curve of plasm concentration versus time equal to ; and the volume of distribution is determined to be
Hint: This equation is slightly different from what was shown in the class, but we can convert the two compartment equations into a single compartment equation using instead of using and This means, the overall drug clearance can be written as Using this equation and you can estimate k
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