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You aim to achieve a steady 1 0 n M plasm concentration of a 7 5 kDa protein. What dosing strategy should you use to

You aim to achieve a steady 10nM plasm concentration of a 75kDa protein. What dosing strategy should you use to administer the molecule? You have the following data from pilot experiments: a 1g tracer dose of protein yields an area under the curve of plasm concentration versus time equal to 10g*hrL; and the volume of distribution is determined to be 5L.
(Hint: This equation is slightly different from what was shown in the class, but we can convert the two compartment equations into a single compartment equation using VD instead of using Vp and Vt. This means, the overall drug clearance can be written as,d([cp]VD)dt=-k[Cp]VD. Using this equation and AC, you can estimate k.)
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