The Darzens condensation is one of the older methods (1904) for the synthesis of three-membered heterocycles. It
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The Darzens condensation is one of the older methods (1904) for the synthesis of three-membered heterocycles. It is most commonly the reaction of a 2-halo ester with a carbonyl derivative in the presence of base. The following examples of the Darzens condensation show how it is applied to the synthesis of oxacyclopropane and azacyclopropane rings. Suggest a reasonable mechanism for each of these reactions.
(a)
(b)
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Organic Chemistry structure and function
ISBN: 978-1429204941
6th edition
Authors: K. Peter C. Vollhardt, Neil E. Schore
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