The drug mechktrethamine is used in antitumor therapy. It is one of a family of compounds called
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The drug mechktrethamine is used in antitumor therapy.
It is one of a family of compounds called nitrogen mustctrds, which also includes the antitumor drugs cyclophosphamide and chlorambucil.
(a) Mechlorethamine undergoes a nucleophilic substitution reaction with water that is several thousand times faster than the nucleophilic substitution reaction of 1,5-dichloropentane. Give the product of the mechlorethamine reaction and the mechanism for its formation.
(b) It is theorized that the antitumor effects of mechlorethamine are due to its reaction with certain nucleophiles in the body. What procluct would you expect from the reaction of mechlorethamine and a general amine R,N:?
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