The karyotype of a young girl who is affected with familial Down syndrome revealed a total of

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The karyotype of a young girl who is affected with familial Down syndrome revealed a total of 46 chromosomes. Her older brother, however, who is phenotypically unaffected, actually had 45 chromosomes. Explain how this could happen. What would you expect to be the chromosomal number in the parents of these two children?
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