Why is 5-fluorouracil a powerful antitumor agent? Why is it considered a suicide substrate?

Question:

Fantastic news! We've Found the answer you've been seeking!

Step by Step Answer:

Related Book For book-img-for-question

Fundamentals of biochemistry Life at the Molecular Level

ISBN: 978-0470547847

4th edition

Authors: Donald Voet, Judith G. Voet, Charlotte W. Pratt

See More Books

Question Posted: Apr 30, 2016 02:52 PM

See More Questions

What is a suicide substrate? Why are they important?
Draw mechanism arrows to show electron movements in the Bergman cycloaromatization reaction that leads to the diradical believed responsible for the DNA-cleaving action of the antitumor agent...
5-Fluorouracil-2-deoxyriboside (FUdR) is used in medicine as an antiviral and antitumor agent. From its name, draw its structure. How do you think FUdR performs its function?
Learning by doing is an integral part of the course experience albeit online. The intent of this assignment is for you to demonstrate your ability to apply course content. Thus in the Marketing...
What is the tax advantage of selling a Section 1231 property at a gain?
The balance sheet contains the same major headings as appear in the accounting equation.
A spacecraft travels at a speed of 0.75c relative to the Earth. The spacecraft then launches a probe at speed v relative to the spacecraft (Fig. P27.26). If the probe has a speed of 0.90c relative to...
The 2018 income statement and comparative balance sheet of Sweet Valley, Inc. follow: SWEET VALLEY, INC. Income Statement Year Ended December 31, 2018 SWEET VALLEY, INC. Comparative Balance Sheet...
Document Inspection Vehicles arrive at the Canadian border at the rate of 140 vehicles per hour, 20% of which are commercial vehicles. All commercial vehicles are required to present documents...
Foreign Exchange Trading at Baldwin Enterprises Baldwin Enterprises is a large manufacturing company with operations and sales divi- sions located in the United States and several other countries....
The small intestine catabolizes amino acids, producing significant amounts of NH4+. Describe the metabolic fate of the NH4+
What is the rationale for administering a high dose of methotrexate followed by a massive amount of N5-formyltetrahydrofolate and thymidine to a cancer patient?
Is red wine better than white wine? Observational studies suggest that moderate use of alcohol by adults reduces heart attacks and that red wine may have special benefits. One reason may be that red...
After further negotiation Roger and Benedicta agreed to use standard preferred stock after all. In her counter-offer, however, Benedicta has proposed that her shares pay cumulative non-cash dividends...
Use the Empirical Rule to answer the questions below: The distribution of weights for newborn babies is approximately normally distributed with a mean of 7.5 pounds and a standard deviation of 0.6...
Assessment Coversheet Unit/s assessed FNSTPB503 Apply Legal Principles in Contract and Consumer Law Assessment name FNSTPB503 Assignment Type of Assessment This summative assessment will enable your...
Question 1 (35 Points) A soil profile is provided below. The estimated stresses from a spread footing overlying a 10 meter thick normally consolidated clay layer are: 180.0 kN/sq m (top of the clay...
What are surrogate keys? Why would you use them in a data warehouse instead of using the business keys from the operational systems?
Use critical values to test the null hypothesis H0: 1 2 = 20 versus the alternative hypothesis H0: 1 2 20 by setting a equal to .10, .05, .01, and .001. How much evidence is there that the...
Describe a key physiological feature of the following Bacteria that would differentiate each from the others: Acetobacter, Methylococcus, Azotobacter, Photobacterium, Desulfovibrio, and Spirillum.
Describe the metabolism for each of the following Bacteria and state whether the organism is an aerobe or an anaerobe: Thiobacillus, Nitrosomonas, Ralstonia eutropha, Methylomonas, Pseudomonas,...
Describe a key feature that would differentiate each of the following Bacteria: Streptococcus, Planctomyces, Verrucomicrobium, and Gemmata.
Harper, Inc, acquires 40 percent of the outstanding voting stock of Kinman Company on January 1, 2020, for $316,100 in cash. The book value of Kinman's net assets on that date was $610.000, although...
Need a help for this! The following information is obtained from the records of Kaiser Company: On January 1, 2017 the following machines were acquired for cash: Production machines costs $ 6,000...
Book 51,500 Hint rint rences Raw Materials Inventory Debit Credit Beginning 10,100 Purchases 45,500 Available for use 55,600 DM used Ending 4,100 Work in Process Inventory Debit Credit Beginning...

Why is 5-fluorouracil a powerful antitumor agent? Why is it considered a suicide substrate?

Question:

Step by Step Answer:

5Fluorouracil is readily taken up by cancer cells and ...View the full answer

Fundamentals of biochemistry Life at the Molecular Level

Students also viewed these Medical Sciences questions